Preheat your oven to 375°F (190°C) and prepare a large baking sheet lined with parchment paper.

In a mixing bowl, combine the ground pork sausage and softened cream cheese until smooth and fully combined.

Stir in the drained Rotel tomatoes and shredded cheddar cheese until evenly incorporated.

Gradually add the Bisquick baking mix, along with garlic powder, onion powder, and black pepper, mixing well.

Roll the mixture into 1-inch balls and place them on the prepared baking sheet with space in between.

Bake for 22-25 minutes or until golden brown, checking for doneness starting at 20 minutes.

Let them cool for about 5 minutes before serving with your favorite dipping sauces.